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Chinese scientists develop electrode coating to address signal loss and tissue adhesion problems in long-term brain-computer interface implantation_我的网站

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一 | 日喀则上午9点突发地震，可中午12点刚过，解放军就火速赶到灾区。打头阵的是200多人的成建制特遣队，他们带着各种救灾装备和大量物资来到受灾群众身边。

Photo: VCG
Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday.
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels.
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions.
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts.
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times.
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
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二 | 同时，无人机在空中侦察，给地面部队提供精准情报，就像给部队装上了“千里眼”。下午，西部战区的运 -20运输机运来战区前沿指挥所，在定日机场落地后，一个覆盖整个灾区的完备指挥体系迅速搭建起来。除了这是救灾不是作战，解放军这次行动完美展示了对高原边境地区的快速反应能力，边境对面的印军看了，或许会有自己的思考。从央视画面能看到，解放军先遣部队通过陆地开进，率先到达地震的山谷。之前无人机已经在空中侦察，绘制了最新地形图，给部队指路。直 -20直升机把特种小队空运到车开不进去的地方。2008年汶川地震到现在区区16年，从解放军的救灾水平能看出我们军队的机动能力进步有多大！2008年汶川地震，当时的救援行动却面临诸多艰难险阻。地震致使交通全面瘫痪，道路垮塌、桥梁断裂，大型救援装备难以运输。徒步挺进的官兵，背负沉重物资，在余震不断、崎岖难行的山路上艰难跋涉。空中救援同样面临困境，直升机数量有限，复杂的气象和地形条件，严重制约了救援物资的投放与人员转运效率。16年过去，解放军的机动能力实现了质的飞跃。运 -20等大型运输机发挥了关键作用，在短时间内将大量的人员、紧缺物资，精准投送至灾区。

三 | 在地面，新型全地形车、高机动性越野装备等大量列装，这些装备能够在各种复杂地形中畅行无阻，快速将救灾人员和物资送达偏远区域。空中方面，直升机不仅数量增多，性能也大幅提升，特别是在高原性能上的优化，实现精准的物资投送与伤员转运。就在地震前几天，央视还播了解放军在高原搞无人化、智能化后勤补给演练，机器狗、无人小车、无人机都用上了，以后高海拔地区补给和保障难的问题，算是解决了。这样一来，解放军能用比印军少很多的兵力，有效控制同样大的边境地区。有无人机、无人平台、直升机和运输机帮忙，解放军合成部队能第一时间出现在防区任何地方，而且装备齐、弹药足，一到就能投入战斗，不用等后续部队。再看印军，他们直升机在高海拔飞不了多久，之前阿帕奇武装直升机发动机熄火，只能拆了用卡车运下山。